L'EMA ha ora completato la sua revisione dell'evidenza derivante dalle
segnalazioni della sindrome dolorosa regionale complessa (CRPS) e della
sindrome da tachicardia posturale ortostatica (POTS).
L'Agenzia Italiana del Farmaco rende disponibili importanti
informazioni di sicurezza riguardanti nuove misure di minimizzazione del rischio di leucoencefalopatia multifocale progressiva (PML) correlato all’uso di Tecfidera nel trattamento della sclerosi multipla.
Labels of all iodinated contrast media (ICM) products will include information about these cases. No changes to current prescribing, administration, or monitoring practices are recommended.
Background
NICE – the National Institute for Clinical Excellence – was established in 1999 by the UK’s Department of Health as an independent body free from political (or other) vested interests. Its remit was to provide advice (“guidance”) to enable health professionals, working in the National Health Service (NHS), to achieve the highest attainable standards of care for their patients.
NICE’s original remit was limited to undertaking “technology appraisals” and to develop “clinical guidelines”. Over the subsequent 15 years, however, its role has been expanded to include other forms of guidance (Table 1). The Institute’s core business, however, remains the production and publication of technology appraisals and clinical guidelines.
Technology appraisals
These provide advice on the clinical and cost effectiveness of predominantly pharmaceutical products. Although, in the early years, it gave advice on the use of devices and diagnostics these have now been subsumed into other guidance programmes (Table 1).
If failure occurs, and the operator does not intervene, the patient may not receive enough oxygen and could suffer serious adverse health consequences, including injury or death.
Identified facility violations could result in an increased risk of infection transmission.
Nello Martini, ex director and founder of the Italian Agency of Medicines (AIFA, in Italian) previously committed for trial by the state’s attorney of Turin Guariniello with the charge of “involuntary disaster” (literal translation of an Italian legal term) for the delayed update of 20 drug information sheets over 15,000, has now been given a full acquittal.
Apparent hyperglycemia
Paediatricians have always dedicated great attention and several diagnostic-therapeutic tools in order to tackle the gastroesophageal reflux, especially in early childhood.
The most recent literature has scaled down the problem, attributing the gastroesophageal reflux to its paraphysiological nature and highlighting the few situations where the gastroesophageal reflux could really become a disease (the so-called gastroesophageal reflux disease, GERD).1,2
Multiple sclerosis (MS) is a demyelinating disease of the central nervous system that usually affects young people with a peak in incidence between 20 and 40 years of age and whose manifestations are focal and diffuse damage from its onset; symptoms vary according to the affected area of the central nervous system.
80.211.154.110
